This book explores the tensions between aesthetics, gender, and disability in contemporary digital media installations and performance art. Notions of agency and subjectivity are connected to four contemporary political issues (artificial intelligence; migration and political violence; contemporary medical technologies and practices; the Anthropocene) and analyzed against a Western legacy of utopian and dystopian ideas and desires that have shaped, and continue to shape, what it means to be human. The book’s main argument is that agency and subjectivity are not universal attributes; rather they are socio-material entanglements and contextually bound enactments that are strategically negotiated by the subject. Thus, they involve conflict, struggle, and other forms of resistance. The book will be of interest to scholars working in art history, media and cultural studies, disability studies, and gender studies.