Businesses have faced a variety of difficulties as a result of the global pandemic, and how they responded to this disruption has affected both their resilience and their ability to get through this crisis. Digital technologies have played a crucial role in addressing these issues and fostering resilience. It is, therefore, imperative to explore options for post-pandemic business transformation and rethinking sustainable development. Handbook of Digital Innovation, Transformation, and Sustainable Development in a Post-Pandemic Era, covers digital innovation and business transformation to build resilience for sustainable development and growth and highlights the impact of supply chain disruptions and solutions to sustain. The handbook stands out for its inclusion of industry cases from various regions across the globe. By presenting the use of big data, blockchain technology, and Industry 4.0, the handbook conveys how to work towards sustainable development and offers self-reliant and sustainable business models. Researchers and practitioners in industrial engineering, engineering management, business management, supply chain management, and digital technologies along with businesses can apply the research and practices covered in the handbook.